Alzheimer’s Drug Comparison – Lecanemab vs Donanemab

After this week’s release of phase 3 trial results for donanemab, a monoclonal antibody that treats Alzheimer’s disease by reducing amyloid beta plaques, I wanted to see how it compared to the last drug with positive results, lecanemab. I made a table comparing the trials side-by-side.  The trials matched identically in a few ways. They … Continue reading Alzheimer’s Drug Comparison – Lecanemab vs Donanemab

Recently Discovered Heart Disease Risk Factor: Lipoprotein(a)

Most cases of cardiovascular disease (CVD) - the category that combines heart disease and stroke - are caused by high LDL cholesterol. When LDL rises above about 90 mg/dl, plaque starts to build up on the vessel walls. If changes to diet and exercise don’t reduce LDL enough, statins, ezetimibe, and PCSK9 inhibitors cause huge … Continue reading Recently Discovered Heart Disease Risk Factor: Lipoprotein(a)

The Coming Revolution in Cancer Screening

The next decade should bring a revolution in early detection of cancer. Today, only four cancers have screenings recommended for the general population: breast, colon, cervix, and lung cancer in smokers. Those cancers only account for 29% of all cases of cancer and 24% of all cancer deaths. Due to low compliance with recommended screenings … Continue reading The Coming Revolution in Cancer Screening

Life Expectancy Calculator by Cause of Death

When am I going to die? The Social Security Administration’s actuarial tables tell me a 32-year-old male has a remaining life expectancy of 46.00 years. To refine that estimate, I can look at papers like this one that compare life expectancy depending on modifiable risk factors. A 50-year-old male who does five healthy things (1. … Continue reading Life Expectancy Calculator by Cause of Death

Preventing Heart Disease with PCSK9 Inhibitors

Powerful new drugs that reduce LDL cholesterol to unprecedented levels with minimal side effects should eliminate heart disease within the next few decades. The primary cause of heart disease is that excessive LDL cholesterol in the blood builds up as plaque inside blood vessels. In my last two posts, I wrote about the first- and … Continue reading Preventing Heart Disease with PCSK9 Inhibitors

Millennials Should Get Screened for Colon Cancer

Rates of colon and rectal cancer (CRC) incidence and death have been decreasing for decades. However, there’s an important exception to this trend. CRC incidence and death has been increasing for people below 50, all the way down to 20 years old. Risk still increases with age, but the difference in risk between 50-year-olds and … Continue reading Millennials Should Get Screened for Colon Cancer